Nicotine inhibits cytokine synthesis by mouse colonic mucosa
نویسندگان
چکیده
منابع مشابه
Nicotine inhibits cytokine synthesis by mouse colonic mucosa.
We examined the in vivo effect of nicotine on the synthesis of (pro)inflammatory mediators by mouse colonic mucosa. The synthesis of lipid mediators such as the prostanoids prostaglandin E2, 6-keto-prostaglandin F1 alpha and thromboxane B2, the 5-lipoxygenase products leukotriene B4 and leukotriene C4 and the platelet activating factor was not affected, whereas the synthesis of the pro-inflamma...
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BACKGROUND Chronic nicotine administration has a dual effect on inflammatory bowel disease: augmentation of jejunitis and amelioration of colitis. We previously showed that chronic nicotine administration has divergent regional effects on small bowel and colonic mucosal mediators and blood flow. OBJECTIVE To examine the effects of nicotine administration on cytokine levels in normal rat small...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 1995
ISSN: 0014-2999
DOI: 10.1016/0014-2999(95)00211-3